Women’s Cancers for Women’s Health Week

Today marks the start of National Women’s Health Week – a fantastic initiative that brings together all kinds of different groups around important issues for women, like physical activity and self-care!  I have the huge honor of guest blogging about women’s cancers over at the American Institute for Cancer Research (AICR) blog today.  AICR is the amazing group behind the reports on nutrition, physical activity and obesity and cancer.  The report, which undergoes continuous updating as new science emerges, is an incredibly comprehensive expert review of the science around food, exercise, weight and cancer.

Check it out the blog and the report!

What makes the “best” science?

In prevention, I’ve noticed something pretty predictable happens when a new study comes out noting the health harms of certain lifestyle factors (alcohol, obesity, and red meat intake are particularly prone to this) – the internet lights up with someone posting (and plenty of others linking) about why we can’t trust anything that comes out of observational studies.

I am not going to sit here and pretend that there aren’t limitations to observational studies – there are and I know them well – that’s what the foundation courses in epidemiology teach you – the limits of each study design.

But let’s be perfectly clear about something else, randomized trials aren’t perfect either.  They aren’t perfect when perfectly conducted and almost none are perfectly conducted.  They can’t be.  Randomized trials are done on people, who are imperfect.  So that means people don’t comply with randomization and they quit the study.

This isn’t news.  If we thought the (THE) randomized trial was perfect, we’d only do one.  So we wouldn’t have need for meta-analyses of randomized trials, which proliferate in the literature.

Randomized trials are subject to interpretation.  One need only to compare how the same set of studies can be interpreted quite differently by the thoracic surgeons  and gastroenterologists when each group issues treatment guidelines.

Does this mean randomized trials are no good?  Absolutely not! In fact I recently wrote a paper with my colleague Graham Colditz about the importance of intervention trials specifically in cancer survivors, though we also noted the limits to what such trials can show.

We need to remember that we can’t (and never will) base all of our health and medical decision making on trial data.  I will continue to trust in the value of parachutes, despite the alarming findings of this analysis of trial data from the esteemed British Medical Journal.

My colleagues at Cancer News In Context & Washington University School of Medicine have put together a nice graphic on the pros and cons of observational versus randomized trial data.  I think it is a nice summary of how BOTH study designs add value to our understanding of health.  Which one is “best” is VERY dependent on the specific question of interest!

The Weight of the Nation

Last night I attended a special screening of HBO’s The Weight of the Nation.  The event, co-hosted by the Consortium to Lower Obesity in Chicago Children (CLOCC), the Chicago Department of Public Health and Comcast demonstrated one of the key points in our Advancing Cancer Prevetnion paper – tackling these large problems is going to require us to come together across traditional disciplinary boundaries.  That doesn’t mean a geneticist and clinical psychologist collaborating.  It means media and science and policy and advocacy all in the same room saying, “ENOUGH.”

After airing part one of the documentary, the event had a panel featuring Dr. Donald Lloyd-Jones, chair of Preventive Medicine at Northwestern (where I had the privilege of completing my post doctoral fellowship, Adam Becker, the Executive Director of CLOCC and Dr. Bechara Choucair from the Chicago Department of Public Health.
The film was outstandingly done.  Because this is what I do for a living, there was very little I didn’t already know content wise in the documentary, but I still found it incredibly compelling.  The HBO filmmakers did a great job of mixing scientific facts, scientist-delivered content, testimonials from individuals and powerful visuals.  The list of scientists they engaged is outstanding.  Besides Dr. Lloyd-Jones, I found the segments with Thomas Frieden (Director of the CDC) and David Nathan (Director of the Diabetes Center at MGH) particularly compelling.  It was also a real treat, as a scientist, to hear Dr. Gerald Berenson talk about his amazing work with the Bogalusa Heart Study.  The Bogalusa Heart Study is the one that first showed us that the foundations of chronic disease start early – in this case, overweight and obese children show signs of heart disease as children!  I also think a huge thank you should go out to the individuals who went on camera and talked about their weight and health struggles.  I am excited to see the remaining segments in the documentary.
I also thoroughly enjoyed the panel and audience discussion.  A couple things stood out -
- everyone recognizes that these aren’t just health problems, they intersect with social and economic issues, particularly for our communities at greatest risk.
- there are a lot of people with incredible passion to do something about this in communities around the country, especially Chicago
- taking actions in other spaces has an impact on health.  The two that were discussed last night I think are worth mentioning.  (1) The biggest piece of legislation that will get voted on in the next year is the Farm Bill.  It has huge consequences on health because it provides enormous subsidies for corn and soybeans.  Kudos to Dr. Lloyd-Jones for urging the audience to talk to our legislators about the Farm Bill. (2) Crime is a major impediment to healthy living in our poor communities – it doesn’t just limit the ability to be active for our kids, but limits job opportunities (meaning longer commutes for parents) and the businesses that will come into those communities (making it harder to get healthy food options).
Here are my favorite quotes from the panel:
“Weight MAINTENANCE is the key to this problem” (Dr. Lloyd-Jones)
“Change is possible and powerful” (Dr. Christoffel from CLOCC)

Does participating in research benefit you?

I saw a post on Twitter recently from Jody (@jodyms), who was so excited to be able to participate in a cancer research trial.  And I was thrilled to see it.  There is a lot of bad information out there about research.  And, yes, there is still too much weak scientific research going on and we haven’t fully accounted for the unethical research practices of our past.  But here’s why we shouldn’t throw the baby out with the bath water.

There is lots of research out there that can help you.

I’m going to do something that may not be really popular, or good for my career, but let me explain how I’d talk to my mom and her friends about participating in research.  Let’s say one of the ladies in my mom’s yoga group, Barb, was approached about participating in a 6 month weight loss trial.  Women of her age and menopausal status are a popular demographic for these kinds of studies that promise 10% body weight loss (or more) in a fairly short time with an intense tightly controlled dietary regimen.  They’ll measure all kinds of physiologic changes.  And this kind of science is valuable – it might provide clues to what happens in the body when weight changes – helping us better understand why weight changes lead to disease risk changes.  Or, as I’ve seen in plenty of grant applications, identify the physiologic or molecular target that we can put a drug on to get the benefit of weight loss for health, without the work of losing weight.  We need people who will participate in trials like these – they are important for advancing science.  But is there a real benefit for Barb?  Honestly, maybe not much.  The study isn’t interested in helping Barb make better, healthier, choices.  They aren’t including the behavioral strategies she needs to achieve long term weight loss.  That’s not their goal. (Harsh? yes.  True? pretty much.)  So when the study is over, Barb will go back to living her life and the weight will likely come back.  (You can say maybe not, but I can pull a pile of studies that show this is what happens – achieving short term weight loss is relatively easy in science, keeping it off is not. Most people gain the weight back, and then some – so they are worse off.)  And it turns out, weight cycling is actually not good for your health.  Maybe participating in that study does more harm than good for Barb.

But what if Barb was approached about participating in a weight maintenance study?  Honestly, it would probably sound a whole lot less appealing to Barb, who’d like to lose a little weight.  But the weight maintenance study is focused on helping Barb make long term changes in her life.  Those that are durable.  Durability is what matters for your risk of heart disease, diabetes and cancer.  Is Barb going to see a benefit from participating in this study? Yup.  Because even if she doesn’t lose any weight, if she doesn’t gain any weight, she’s better off.  The reality is there all kinds of in between and Barb needs to know what she’s getting and what she’s not getting.

I’m not saying people shouldn’t participate in trials that provide them with no direct personal benefit.  The generous men and women who have knowingly volunteered to do so have advanced science in countless, critical ways. My lab does BOTH kinds of studies.  We ask people to complete surveys during their cancer care that will provide us with important information to identify intervention targets and it won’t directly benefit the men and women who complete those surveys.  But there is also science out there that can benefit the participants, directly, and we do this science too.  If you aren’t willing to do the former, you might be willing to do the later.  If you’re asked to participate in a research study, ask the questions and find out more before you say no.  It might be a study that helps us advance science or it might be one that helps you AND advances science.

American Cancer Society Guidelines for Survivors

The American Cancer Society recently released a revision to their nutrition and physical activity guidelines for cancer survivors.  The guidelines were compiled by an expert panel that reviewed the wealth of new evidence that has been published since the original guidelines were released in 2006.  While many of the guidelines are similar to those for cancer prevention, the proliferation of high quality science in the subsequent years has led to some key refinements in the messages.

Here are a few highlights:

- When it comes to question of nutrition and physical activity, “survivors soon find there are few clear answers to even the simplest questions.” What the evidence base shows is that the answers on what foods or what exercise will likely vary , in some regards, from one cancer to another (remember, we say “cancer,” but we’re talking about dozens of diseases) and based on treatment type as well as numerous other individual level factors.  Despite this and that more research needs to be done to fill in the gaps (e.g., more than 80% of the intervention evidence for the safety and efficacy of exercise in survivors comes from breast cancer populations), recommendations on exercise and diet can and have been made.

- The ACS guidelines are for primarily targeted to health care providers.  (Exercise professionals looking for field specific guidance can turn to the ACSM guidelines.) Why target providers? “Physicians and other health care providers have a unique opportunity to guide cancer patients toward optimal lifestyle choices, and thus can favorably influence the survivorship trajectory regardless of the individual’s survivorship phase. The power of physician advice in facilitating preventive health behaviors has been consistently demonstrated.” Patients look to providers for information.  Unfortunately, physicians aren’t always well informed about the evidence for the importance of lifestyle. (Many are, but it is more common for me to meet an oncologist surprised at the depth of evidence for the benefits of exercise among survivors than to meet one who is well versed in it.) These guidelines are an important part of that education and outreach process.  Physicians need not do all the counseling themselves, but do need to provide referrals to the appropriate followup lifestyle care such as with a certified fitness professional or nutritionist.

-Addressed with new gusto in the ACS guidelines is supplement use, with good reason. “A recent systematic review indicates that 14% to 32% of cancer survivors initiate supplement use after their diagnosis. Breast cancer survivors report the highest prevalence of supplement use, whereas prostate cancer survivors report the lowest.” Despite the high prevalence of use, the guidelines note, “dietary supplements are unlikely to improve prognosis or overall survival after the diagnosis of cancer, and may actually increase mortality.” The appeal of supplements is logical – people often feel they are struggling to get adequate nutrients through foods, and a whole industry exists to play to that concern.  But the guidelines are clear: “Before supplements are prescribed or taken, all attempts should be made to obtain needed nutrients through dietary sources. Supplements should be considered only if a nutrient deficiency is either biochemically (eg, low plasma vitamin D levels, B12 deficiency) or clinically (eg, low bone density) demonstrated. Supplements should be considered if nutrient intakes fall persistently below two-thirds of the recommended intake levels. Such a determination should be made by a registered dietitian.

The supplements provide a nice example of why patient provider communication is key to healthy survivorship.  If providers don’t know what patients are doing, eating, taking, they can’t provide the recommendations of what to continue and what to change.  As the guidelines note, “Open dialogue between patients and health care providers should occur regarding dietary supplementation to ensure there is no contraindication in relation to the prescribed cancer therapy or for longer term health effects.”  In fact, open dialog is important for making any lifestyle change!

Counting time or counting steps?

I caught a story on NPR’s Morning Edition that made me do a double take. Thanks to a new book, the decades old concept of getting 10,000 steps per day, as measured by a pedometer, is getting headlines.  This is great because pedometers have underpinned health research, including that in my lab, for years.  The NPR story argues the 10,000 step metric is wrong and we should focus on getting 30 minutes of moderate intensity walking (enough to ramp up yor heart rate) five days a week (150 minutes/week). So which one is right? How do you know if you’re doing enough? Turns out they are both right.

There is lots of evidence that people who get, on average, 30 minutes a day of walking, have lower rates of heart disease, diabetes, stroke and some cancers.  But most of that science hasn’t specifically studied 30 minutes per day.  Some of the people who expended that amount of energy did so by doing more intense activity for less time, or for a longer time on fewer days.  Does that make the 30 minute recommendation wrong? No! But it also isn’t the only way.  And remember that doing more is even better in those studies.  We call it a dose response – up the dose and you up the response ( in this case, lower the risk).  And that’s why the recommendation is actually no longer 30 minutes for 5 days, but 30 minutes for most days – ideally ALL days.

Now what about those 10,000 steps I’ve been recording on my pedometer? In the NPR story, they said you have to walk 5 miles to get there and it takes 2 hours to get it – four times that 30 minute walk.  Do the steps mean nothing? Or do you need to do so much more if you are using the step metric instead of the time one? Goodness no.  On BOTH.

The recommendations comes from much of the same science.  Here’s the science (& math).  The average healthy adult gets between 6000 and 8500 steps per day just going about her daily life (those who are sedentary or suffering from a chronic disease get 3500 to 5000 steps per day and younger adults more like 7-13,000 steps).  A brisk 30 minute walk accumulates about 3-4000 steps.  So an average adult going about her day who adds a 30 minute walk would get about 10,000 steps per day.  Making the recommendations about the same.

The benefit of the 10,000 steps per day recommendation is that it merges two distinct, but important concepts in science – being active and not being sedentary.  It turns out, regardless of how much exercise you get, people who sit more are at higher risk for disease.  So a person who is sedentary (getting 3500 steps per day) who adds a 30  minute walk will be at about 7000 steps per day.  Is this person better off, healthwise, than the one who didn’t take the walk? ABSOLUTELY.  But is he doing as well as the person who doesn’t sit all day AND gets a 30 minute walk? Nope.

Think about it like this.  If you drive to work and sit around the office all day, drive home, heat up dinner in the microwave and sit around for the rest of the evening (whether you are reading or watching TV provided you aren’t snacking, it doesn’t matter for the purposes of this example), you might get only 2500 steps the whole day.  I know this because I’ve had days like that.  Even if I add a 30 minute walk in there, I’m still largely sedentary.  But if I walk to the train and make an effort to go down the hall to discuss a project with my colleague instead of emailing her, if I get up and pace the hallway for a minute instead of checking the ESPN headlines, I’m over 5000 steps, maybe even 6000 steps before I even take a purposeful walk.

The pedometer also keeps people honest.  We don’t intentionally lie to ourselves about these things, but that 6 minute walk to and from the train becomes 10 each way and the 10 minute walk with the dog becomes a walk, not 2 minutes of walking and 8 minutes of standing around during sniffing and stuff.  Suddenly, 15 minutes is 30. But the steps are steps.

The ideal is both an active day and purposeful walking.  Not either or.  And saying the former is better ignores the science about the dangers of sitting.  Which shows not moving all day is bad, regardless of our exercise.  And if you read between the lines, the NPR story says as much, since their expert advocates for walking meetings, which might not be vigorous enough to “count” toward that 30 minutes of moderate intensity exercise the science says we need to reduce chronic disease risk.  Remember, it isn’t a 30 minute leisure stroll!

So if you’re taking a 30 minute walk and your pedometer is only at 6000 steps at bedtime – is that a failure? No. In our research, we know to tailor the goal to the audience.  And thanks to our understanding g of dose response, we know there’s a benefit to something over nothing.

In our cancer prevention segment on activity we introduced Virginia.  She’s closer to a 6-8000 steps per day person some days after our intervention (But working hard to keep doing more!). But her blood pressure is down and her glucose regulation is better. Do I think our intervention didn’t work because she didn’t hit 10,000 steps? Not even close.  Because the other thing about that step counting helps is the durability. More than a year after the intervention ended, she’s still walking and counting steps.  The pedometer gives her credit for what she does – she knows more is better but we also know something is better than nothing!  And for chronic diseases we know it is long term behavior change that matters most.

No rest for the weary

Following closely on the heels of the American College of Sports Medicine Exercise Guidelines for Cancer SurvivorsMacMillan Cancer Support in the UK launched a Move More campaign designed to get cancer survivors up and moving. The goal is also to debunk the notion that rest is best for cancer survivors during and after treatment. (Remember, we used to think that rest was best after a heart attack and now cardiac rehab is a key part of the recovery process.)

As part of their campaign, MacMillan reviewed the evidence supporting a role for exercise in survivors. Expanding on the ACSM focus on clinical trials, the MacMillan report includes observational data – notably showing that exercise reduces risk of recurrence and death in breast, colorectal and prostate cancer survivors. The MacMillan website holds a wealth of information, directed at survivors, on how to go about safely being active. The benefits of activity, what we mean by activity, how to safely be active and how to get started are all covered in great detail.

For other ways to stay healthy after a cancer diagnosis, check out Cancer Survivors’ 8 Ways. For more on how exercise can help prevent cancer, click over to my overview video from the Siteman Cancer Center 8 ways campaign.

Follow

Get every new post delivered to your Inbox.